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    Role of a cdk5-associated protein, p35, in herpes simplex virus type 1 replication in vivo

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    Haenchen_2010.pdf (101.2Kb)
    Issue Date
    2013-10
    Author
    Haenchen, Steve D.
    Utter, Jeff A.
    Bayless, Adam M.
    Dobrowsky, Rick T.
    Davido, David J.
    Publisher
    Springer Verlag
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Rights
    © Journal of NeuroVirology, Inc. 2010
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    Abstract
    Previous studies have shown that herpes simplex virus type 1 (HSV-1) replication is inhibited by the cyclin-dependent kinase (cdk) inhibitor roscovitine. One roscovitine-sensitive cdk that functions in neurons is cdk5, which is activated in part by its binding partner, p35. Because HSV establishes latent infections in sensory neurons, we sought to determine the role p35 plays in HSV-1 replication in vivo. For these studies, wild-type (wt) and p35-/- mice were infected with HSV-1 using the mouse ocular model of HSV latency and reactivation. The current results indicate that p35 is an important determinant of viral replication in vivo.
    URI
    http://hdl.handle.net/1808/24302
    DOI
    https://doi.org/10.3109/13550284.2010.513030
    Collections
    • Molecular Biosciences Scholarly Works [530]
    Citation
    Haenchen, S.D., Utter, J.A., Bayless, A.M. et al. Journal of NeuroVirology (2010) 16: 405. doi:10.3109/13550284.2010.513030

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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