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dc.contributor.authorWang, Qun
dc.contributor.authorJamal, Syed A.
dc.contributor.authorDetamore, Michael S.
dc.contributor.authorBerkland, Cory J.
dc.date.accessioned2017-05-19T15:20:06Z
dc.date.available2017-05-19T15:20:06Z
dc.date.issued2011-03-01
dc.identifier.citationWang, Q., Jamal, S., Detamore, M. S. and Berkland, C. (2011), PLGA-chitosan/PLGA-alginate nanoparticle blends as biodegradable colloidal gels for seeding human umbilical cord mesenchymal stem cells. J. Biomed. Mater. Res., 96A: 520–527. doi:10.1002/jbm.a.33000en_US
dc.identifier.urihttp://hdl.handle.net/1808/24243
dc.description.abstractThe natural polymers chitosan and alginate represent an attractive material choice for biodegradable inplants. These were used as coating materials to make positively and negatively charged PLGA nanoparticles, respectively. After blending at total solids concentration >10% wt/vol, these oppositely charged nanoparticles yielded a cohesive colloidal gel. Electrostatic forces between oppositely charged nanoparticles produced a stable 3-D porous network that may be extruded or molded to the desired shape. This high concentration colloidal system demonstrated shear-thinning behavior due to the disruption of interparticle interactions. Once the external force was removed, the cohesive property of the colloidal gel was recovered. Scanning electron micrographs of dried colloidal networks revealed an organized, 3-D microporous structure. Rheological studies were employed to probe the differences in plasticity and shear sensitivity of colloidal gels. Viability tests of hUCMSCs seeded on the colloidal gels also demonstrated the negligible cytotoxicity of the materials. All the results indicated the potential application of the biodegradable colloidal gels as an injectable scaffold in tissue engineering and drug release.en_US
dc.publisherWileyen_US
dc.rightsThis is the peer reviewed version of the following article: Wang, Q., Jamal, S., Detamore, M. S. and Berkland, C. (2011), PLGA-chitosan/PLGA-alginate nanoparticle blends as biodegradable colloidal gels for seeding human umbilical cord mesenchymal stem cells. J. Biomed. Mater. Res., 96A: 520–527. doi:10.1002/jbm.a.33000, which has been published in final form at http://doi.org/10.1002/jbm.a.33000. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en_US
dc.subjectPLGAen_US
dc.subjectNatural polymersen_US
dc.subjectColloidal gelen_US
dc.subjectTissue engineeringen_US
dc.titlePLGA-chitosan/PLGA-alginate Nanoparticle Blends as Biodegradable Colloidal Gels for Seeding Human Umbilical Cord Mesenchymal Stem Cellsen_US
dc.typeArticleen_US
kusw.kuauthorWang, Qun
kusw.kuauthorJamal, Syed
kusw.kuauthorDetamore, Michael S.
kusw.kuauthorBerkland, Cory J.
kusw.kudepartmentChemical and Petroleum Engineeringen_US
kusw.kudepartmentMolecular Biosciencesen_US
kusw.kudepartmentPharmaceutical Scienceen_US
dc.identifier.doi10.1002/jbm.a.33000en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC3080015en_US
dc.rights.accessrightsopenAccess


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