dc.contributor.author | Wang, Qun | |
dc.contributor.author | Jamal, Syed A. | |
dc.contributor.author | Detamore, Michael S. | |
dc.contributor.author | Berkland, Cory J. | |
dc.date.accessioned | 2017-05-19T15:20:06Z | |
dc.date.available | 2017-05-19T15:20:06Z | |
dc.date.issued | 2011-03-01 | |
dc.identifier.citation | Wang, Q., Jamal, S., Detamore, M. S. and Berkland, C. (2011), PLGA-chitosan/PLGA-alginate nanoparticle blends as biodegradable colloidal gels for seeding human umbilical cord mesenchymal stem cells. J. Biomed. Mater. Res., 96A: 520–527. doi:10.1002/jbm.a.33000 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/24243 | |
dc.description.abstract | The natural polymers chitosan and alginate represent an attractive material choice for biodegradable inplants. These were used as coating materials to make positively and negatively charged PLGA nanoparticles, respectively. After blending at total solids concentration >10% wt/vol, these oppositely charged nanoparticles yielded a cohesive colloidal gel. Electrostatic forces between oppositely charged nanoparticles produced a stable 3-D porous network that may be extruded or molded to the desired shape. This high concentration colloidal system demonstrated shear-thinning behavior due to the disruption of interparticle interactions. Once the external force was removed, the cohesive property of the colloidal gel was recovered. Scanning electron micrographs of dried colloidal networks revealed an organized, 3-D microporous structure. Rheological studies were employed to probe the differences in plasticity and shear sensitivity of colloidal gels. Viability tests of hUCMSCs seeded on the colloidal gels also demonstrated the negligible cytotoxicity of the materials. All the results indicated the potential application of the biodegradable colloidal gels as an injectable scaffold in tissue engineering and drug release. | en_US |
dc.publisher | Wiley | en_US |
dc.rights | This is the peer reviewed version of the following article: Wang, Q., Jamal, S., Detamore, M. S. and Berkland, C. (2011), PLGA-chitosan/PLGA-alginate nanoparticle blends as biodegradable colloidal gels for seeding human umbilical cord mesenchymal stem cells. J. Biomed. Mater. Res., 96A: 520–527. doi:10.1002/jbm.a.33000, which has been published in final form at http://doi.org/10.1002/jbm.a.33000. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | en_US |
dc.subject | PLGA | en_US |
dc.subject | Natural polymers | en_US |
dc.subject | Colloidal gel | en_US |
dc.subject | Tissue engineering | en_US |
dc.title | PLGA-chitosan/PLGA-alginate Nanoparticle Blends as Biodegradable Colloidal Gels for Seeding Human Umbilical Cord Mesenchymal Stem Cells | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Wang, Qun | |
kusw.kuauthor | Jamal, Syed | |
kusw.kuauthor | Detamore, Michael S. | |
kusw.kuauthor | Berkland, Cory J. | |
kusw.kudepartment | Chemical and Petroleum Engineering | en_US |
kusw.kudepartment | Molecular Biosciences | en_US |
kusw.kudepartment | Pharmaceutical Science | en_US |
dc.identifier.doi | 10.1002/jbm.a.33000 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC3080015 | en_US |
dc.rights.accessrights | openAccess | |