| dc.contributor.author | Moore, Blake P. | |
| dc.contributor.author | Chung, Dong-Hoon | |
| dc.contributor.author | Matharu, Daljit S. | |
| dc.contributor.author | Golden, Jennifer E. | |
| dc.contributor.author | Maddox, Clinton | |
| dc.contributor.author | Rasmussen, Lynn | |
| dc.contributor.author | Noah, James W. | |
| dc.contributor.author | Sosa, Melinda | |
| dc.contributor.author | Ananthan, Subramaniam | |
| dc.contributor.author | Tower, Nichole A. | |
| dc.contributor.author | White, E. Lucile | |
| dc.contributor.author | Jia, Fuli | |
| dc.contributor.author | Prisinzano, Thomas E. | |
| dc.contributor.author | Aubé, Jeffrey | |
| dc.contributor.author | Jonsson, Colleen B. | |
| dc.contributor.author | Severson, William E. | |
| dc.date.accessioned | 2017-04-06T16:00:41Z | |
| dc.date.available | 2017-04-06T16:00:41Z | |
| dc.date.issued | 2012-10-25 | |
| dc.identifier.citation | Moore, B. P., Chung, D. H., Matharu, D. S., Golden, J. E., Maddox, C., Rasmussen, L., … Severson, W. E. (2012). (S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a Small Molecule Inhibitor Probe for the Study of Respiratory Syncytial Virus Infection. Journal of Medicinal Chemistry, 55(20), 8582–8587. http://doi.org/10.1021/jm300612z | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/23581 | |
| dc.description.abstract | A high-throughput, cell-based screen was used to identify chemotypes as inhibitors for human respiratory syncytial virus (hRSV). Optimization of a sulfonylpyrrolidine scaffold resulted in compound 5o that inhibited a virus-induced cytopathic effect in the entry stage of infection (EC50 = 2.3 ± 0.8 µM) with marginal cytotoxicity (CC50 = 30.9 ± 1.1 µM) and reduced viral titer by 100-fold. Compared to ribavirin, sulfonylpyrrolidine 5o demonstrated an improved in vitro potency and selectivity index. | en_US |
| dc.publisher | American Chemical Society | en_US |
| dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Medicinal Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jm300612z. | en_US |
| dc.title | (S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a Small Molecule Inhibitor Probe for the Study of Respiratory Syncytial Virus Infection | en_US |
| dc.type | Article | en_US |
| kusw.kuauthor | Matharu, Daljit S. | |
| kusw.kuauthor | Golden, Jennifer E. | |
| kusw.kuauthor | Prisinzano, Thomas E. | |
| kusw.kuauthor | Aubé, Jeffrey | |
| kusw.kudepartment | Specialized Chemistry Center | en_US |
| kusw.kudepartment | Medicinal Chemistry | en_US |
| dc.identifier.doi | 10.1021/jm300612z | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0003-1049-5767 | |
| dc.identifier.orcid | https://orcid.org/0000-0002-6813-3710 | |
| kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.rights.accessrights | openAccess | |
