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dc.contributor.authorMorris, J. K.
dc.contributor.authorVidoni, Eric D.
dc.contributor.authorPerea, R. D.
dc.contributor.authorRada, R.
dc.contributor.authorJohnson, David K.
dc.contributor.authorLyons, Kelly E.
dc.contributor.authorPahwa, Rajesh
dc.contributor.authorBurns, Jeffrey M.
dc.contributor.authorHonea, Robyn A.
dc.date.accessioned2017-02-16T20:46:24Z
dc.date.available2017-02-16T20:46:24Z
dc.date.issued2014-06-13
dc.identifier.citationMORRIS, J. K., VIDONI, E. D., PEREA, R. D., RADA, R., JOHNSON, D. K., LYONS, K., … HONEA, R. A. (2014). INSULIN RESISTANCE AND GRAY MATTER VOLUME IN NEURODEGENERATIVE DISEASE. Neuroscience, 270, 139–147. http://doi.org/10.1016/j.neuroscience.2014.04.006en_US
dc.identifier.urihttp://hdl.handle.net/1808/23199
dc.description.abstractThe goal of this study was to compare insulin resistance in aging and aging-related neurodegenerative diseases, and to determine the relationship between insulin resistance and gray matter volume (GMV) in each cohort using an unbiased, voxel-based approach. Insulin resistance was estimated in apparently healthy elderly control (HC, n = 21) and neurodegenerative disease (Alzheimer’s disease (AD), n = 20; Parkinson’s disease (PD), n = 22) groups using Homeostasis Model Assessment of Insulin Resistance 2 (HOMA2) and intravenous glucose tolerance test (IVGTT). HOMA2 and GMV were assessed within groups through General Linear Model multiple regression. We found that HOMA2 was increased in both AD and PD compared to the HC group (HC vs. AD, p = 0.002, HC vs. PD, p = 0.003), although only AD subjects exhibited increased fasting glucose (p = 0.005). Furthermore, our voxel-based morphometry analysis revealed that HOMA2 was related to GMV in all cohorts in a region-specific manner (p < 0.001, uncorrected). Significant relationships were observed in the medial prefrontal cortex (HC), medial temporal regions (AD), and parietal regions (PD). Finally, the directionality of the relationship between HOMA2 and GMV was disease-specific. Both HC and AD subjects exhibited negative relationships between HOMA2 and brain volume (increased HOMA2 associated with decreased brain volume), while a positive relationship was observed in PD. This cross-sectional study suggests that insulin resistance is increased in neurodegenerative disease, and that individuals with AD appear to have more severe metabolic dysfunction than individuals with PD or PD dementia.en_US
dc.publisherElsevieren_US
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectInsulin resistanceen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectParkinson’s diseaseen_US
dc.subjectDementiaen_US
dc.subjectMetabolismen_US
dc.subjectGlucose toleranceen_US
dc.titleInsulin Resistance and Gray Matter Volume in Neurodegenerative Diseaseen_US
dc.typeArticleen_US
kusw.kuauthorJohnson, D.K.
kusw.kudepartmentPsychologyen_US
dc.identifier.doi10.1016/j.neuroscience.2014.04.006en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-0496-1445
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Except where otherwise noted, this item's license is described as: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.