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dc.contributor.authorOien, Derek B.
dc.contributor.authorOsterhaus, Gregory L.
dc.contributor.authorLundquist, Brandi L.
dc.contributor.authorFowler, Stephen C.
dc.contributor.authorMoskovitz, Jackob
dc.date.accessioned2017-02-16T19:50:19Z
dc.date.available2017-02-16T19:50:19Z
dc.date.issued2010-01
dc.identifier.citationOien, D. B., Osterhaus, G. L., Lundquist, B. L., Fowler, S. C., & Moskovitz, J. (2010). Caloric restriction alleviates abnormal locomotor activity and dopamine levels in the brain of the methionine sulfoxide reductase A knockout mouse. Neuroscience Letters, 468(1), 38–41. http://doi.org/10.1016/j.neulet.2009.10.058en_US
dc.identifier.urihttp://hdl.handle.net/1808/23193
dc.description.abstractOxidative stress is associated with the aging process, a risk factor for neurodegenerative diseases, and decreased by reduced energy intake. Oxidative modifications can affect protein function; the sulfur-containing amino acids, including methionine, are particularly susceptible to oxidation. A methionine sulfoxide can be enzymatically reduced by the methionine sulfoxide reductase (Msr) system. Previously, we have shown that MsrA−/− mice exhibit altered locomotor activity and brain dopamine levels as function of age. Previous studies have demonstrated that a caloric restriction enhances antioxidant defense and reduces the action of reactive oxygen species. Here we examine locomotor behavior and dopamine levels of MsrA−/− mice after caloric restriction starting at 8 months of age and ending at 17 months. The MsrA−/− mice did not have any significant difference in spontaneous distance traveled when compared to controls at 17 months of age. In contrast, our previous report showed decreased locomotor activity in the MsrA−/− mice at 12 months of age and older when fed ad-libitum. After completion of the caloric restriction diet, dopamine levels were comparable to control mice. This differs from the abnormal dopamine levels previously observed in MsrA−/− mice fed ad-libitum. Thus, caloric restriction had a neutralization effect on MsrA ablation. In summary, it is suggested that caloric restriction alleviates abnormal locomotor activity and dopamine levels in the brain of the methionine sulfoxide reductase A knockout mouse.en_US
dc.publisherElsevieren_US
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectOxidative stressen_US
dc.subjectProtein oxidationen_US
dc.subjectCaloric restrictionen_US
dc.subjectLocomotor activityen_US
dc.subjectDopamineen_US
dc.subjectAgingen_US
dc.titleCaloric restriction alleviates abnormal locomotor activity and dopamine levels in the brain of the methionine sulfoxide reductase A knockout mouseen_US
dc.typeArticleen_US
kusw.kuauthorOien, Derek B.
kusw.kuauthorOsterhaus, Gregory L.
kusw.kuauthorLundquist, Brandi L.
kusw.kuauthorFowler, Stephen C.
kusw.kuauthorMoskovitz, Jackob
kusw.kudepartmentPharmacology and Toxicologyen_US
dc.identifier.doi10.1016/j.neulet.2009.10.058en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Except where otherwise noted, this item's license is described as: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.