The Association of Benzodiazepine Use with Smoking Cessation Among Hospitalized Smokers in a Clinical Trial
Issue Date
2016-05-31Author
Wilson, Austin T.
Publisher
University of Kansas
Format
18 pages
Type
Thesis
Degree Level
M.S.
Discipline
Clinical Research
Rights
Copyright held by the author.
Metadata
Show full item recordAbstract
Objective: Benzodiazepines are an increasingly prescribed class of anxiolytic medications that target GABA-A receptors in the brain. Smoking also has indirect effects on GABA receptors. This secondary data analysis evaluates the effects of benzodiazepine use on smoking cessation rates among participants in a hospital-based cessation trial. To our knowledge, no other study has examined the effect of benzodiazepine use on smoking cessation rates. Methods: Data from the Enhancing Quitline Utilization among In-Patients (EQUIP) study was analyzed as part of a secondary data analysis. Participants with a benzodiazepine prescription listed on their hospital discharge medication list were compared with those without a benzodiazepine prescription (total n=1054). Similar analyses were conducted between participants with either a long- or short-acting benzodiazepine prescription. Results: A logistic regression modeling the odds of a participant quitting showed no statistical association with benzodiazepine prescription presence (Odds Ratio, OR, 0.93, 95% confidence interval 0.68, 1.28). Controlling for potential covariates maintained a negatively associated, non-significant OR of 0.88 (95% confidence interval 0.63, 1.22). Additionally, the logistic regression modeling produced non-significant odds ratios for both unadjusted and adjusted associations of long-acting versus short-acting benzodiazepine prescription presence on quit rates (adjusted O.R. 0.88, 95% confidence interval 0.49, 1.61). Conclusions: In this sample of patients, the presence of a benzodiazepine prescription at discharge did not have a significant effect on 6-month biochemically verified quit rates. The odds of being quit based on the presence of a benzodiazepine prescription at discharge trended negatively across all unadjusted and adjusted analyses.
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