Application of a Double Aza-Michael Reaction in a ‘Click, Click, Cy-Click’ Strategy: From Bench to Flow

Zang, Qin; Javed, Salim; Ullah, Farman; Zhou, Aihua; Knudtson, Christopher Anton; Bi, Danse; Basha, Fatima Z.; Organ, Michael G.; Hanson, Paul R.

dc.contributor.author	Zang, Qin
dc.contributor.author	Javed, Salim
dc.contributor.author	Ullah, Farman
dc.contributor.author	Zhou, Aihua
dc.contributor.author	Knudtson, Christopher Anton
dc.contributor.author	Bi, Danse
dc.contributor.author	Basha, Fatima Z.
dc.contributor.author	Organ, Michael G.
dc.contributor.author	Hanson, Paul R.
dc.date.accessioned	2017-01-05T18:05:15Z
dc.date.available	2017-01-05T18:05:15Z
dc.date.issued	2011-03-18
dc.identifier.citation	Organ, Michael, Paul Hanson, Qin Zang, Salim Javed, Farman Ullah, Aihua Zhou, Christopher Knudtson, Danse Bi, and Fatima Basha. "Application of a Double Aza-Michael Reaction in a â Click, Click, Cy-Clickâ Strategy: From Bench to Flow." Synthesis 2011.17 (2011): 2743-750.	en_US
dc.identifier.uri	http://hdl.handle.net/1808/22459
dc.description.abstract	The development of a ‘click, click, cy-click’ process utilizing a double aza-Michael reaction to generate functionalized 1,2,5-thiadiazepane 1,1-dioxides is reported. Optimization in flow, followed by scale out of the inter-/intramolecular double aza-Michael addition has also been realized using a microwave-assisted, continuous flow organic synthesis platform (MACOS). In addition, a facile one-pot, sequential strategy employing in situ Huisgen cycloaddition post-double aza-Michael has been accomplished, and is applicable to library synthesis.	en_US
dc.publisher	Thieme Publishing	en_US
dc.relation.isversionof	https://www.thieme-connect.de/products/ejournals/html/10.1055/s-0030-1260112	en_US
dc.subject	Double-aza-Michael	en_US
dc.subject	Click	en_US
dc.subject	MACOS	en_US
dc.subject	Flow	en_US
dc.subject	1	en_US
dc.subject	2	en_US
dc.subject	5-thia-diazepane 1	en_US
dc.subject	1-dioxides	en_US
dc.title	Application of a Double Aza-Michael Reaction in a ‘Click, Click, Cy-Click’ Strategy: From Bench to Flow	en_US
dc.type	Article	en_US
kusw.kuauthor	Javed, Salim
kusw.kudepartment	Chemistry	en_US
dc.identifier.doi	10.1055/s-0030-1260112	en_US
kusw.oaversion	Scholarly/refereed, publisher version	en_US
kusw.oapolicy	This item meets KU Open Access policy criteria.	en_US
dc.rights.accessrights	openAccess

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