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    Commensurate Priors on a Finite Mixture Model for Incorporating Repository Data in Clinical Trials

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    Issue Date
    2016-02-02
    Author
    Gajewski, Byron J.
    Reese, C. Reese
    Colombo, John
    Carlson, Susan E.
    Publisher
    Taylor and Francis
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
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    Abstract
    Docosahexaenoic acid (DHA) is a good source of fat that can be taken up through food, such as fish, or taken as a supplement. Evidence is building that DHA provides a high-yield, low-risk strategy to reduce preterm birth and/or low birth weight. These births are great costs to society. A recently completed Phase III trial revealed that higher birth weight and gestational age were associated with DHA dosed at 600 mg/day. In this article, we take a posterior predictive approach to assess impacts of these findings on public health. Simple statistical models are not adequate for accurate posterior predictive distribution estimation. Of particular interest is that the joint distribution of birth weight and gestational age is well modeled by a finite mixture of three normal distributions. Data from our own clinical trial exhibit similar features. Using the mean and variance-covariance matrices from a previous study and flexible commensurate priors for the mixing parameters, we estimate the effect of DHA supplementation on over 20,000 infants born in hospitals demographically similar to the hospital where the clinical trial was conducted.
    URI
    http://hdl.handle.net/1808/21023
    DOI
    https://doi.org/10.1080/19466315.2015.1133453
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    • Life Span Institute Scholarly Works [127]
    Citation
    Byron J. Gajewski , C. Shane Reese , John Colombo , Susan E. Carlson. "Commensurate Priors on a Finite Mixture Model for Incorporating Repository Data in Clinical Trials." Statistics in Biopharmaceutical Research, 8(2): 151-160 (2016). DOI: 10.1080/19466315.2015.1133453

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    KU Libraries
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    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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