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dc.contributor.authorUrbanska, Aleksandra Malgorzata
dc.contributor.authorPaul, Arghya
dc.contributor.authorBhahena, Jasmine
dc.contributor.authorPrakash, Satya
dc.date.accessioned2015-10-16T14:07:11Z
dc.date.available2015-10-16T14:07:11Z
dc.date.issued2010-08
dc.identifier.citationUrbanska, Aleksandra Malgorzata, Arghya Paul, Jasmine Bhahena, and Satya Prakash. "Suppression of Tumorigenesis: Modulation of Inflammatory Cytokines by Oral Administration of Microencapsulated Probiotic Yogurt Formulation." International Journal of Inflammation 2010 (2010): 1-10. http://dx.doi.org/10.4061/2010/894972en_US
dc.identifier.urihttp://hdl.handle.net/1808/18698
dc.description.abstractThe objective of this study was to examine the ability of a novel microencapsulated probiotic yogurt formulation to suppress the intestinal inflammation. We assessed its anticancer activity by screening interleukin-1, 6, and 12 (IL-1, 6, 12), secretory levels of tumor necrosis factor-alpha (TNF- ), interferon-gamma (IFN- ), prostaglandin , and thromboxane B2 in the digesta obtained from the duodenum, jejunum, proximal, and distal segments of the ileum of C57BL/6J- /J mice. Formulation-receiving animals showed consistently lower proinflammatory cytokines' levels when compared to control group animals receiving empty alginate-poly-L-lysine-alginate (APA) microcapsules suspended in saline. The concentrations of IL-12 found in serum in control and treatment group animals were significant:  pg/mL and  pg/mL for control and treatment animals, respectively. We determined a significant change in plasma C-reactive protein:  ng/mL in control group and  ng/mL in treatment group. Western blots showed a 71% downregulation of cyclooxygenase-2 (COX-2) protein in treatment group animals compared to control. These results point to the possibility of using this yogurt formulation in anticancer therapies, in addition to chronic gut diseases such as Crohn's disease, irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD) thanks to its inflammation lowering properties.en_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.isversionofdx:10.4061/2010/894972en_US
dc.rightsCopyright © 2010 Aleksandra Malgorzata Urbanska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleSuppression of Tumorigenesis: Modulation of Inflammatory Cytokines by Oral Administration of Microencapsulated Probiotic Yogurt Formulationen_US
dc.typeArticle
kusw.kuauthorPaul, Arghya
kusw.kudepartmentChemical & Petroleum Engren_US
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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Copyright © 2010 Aleksandra Malgorzata Urbanska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as: Copyright © 2010 Aleksandra Malgorzata Urbanska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.