Suppression of Tumorigenesis: Modulation of Inflammatory Cytokines by Oral Administration of Microencapsulated Probiotic Yogurt Formulation
Issue Date
2010-08Author
Urbanska, Aleksandra Malgorzata
Paul, Arghya
Bhahena, Jasmine
Prakash, Satya
Publisher
Hindawi Publishing Corporation
Type
Article
Article Version
Scholarly/refereed, publisher version
Published Version
dx:10.4061/2010/894972Rights
Copyright © 2010 Aleksandra Malgorzata Urbanska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Show full item recordAbstract
The objective of this study was to examine the ability of a novel microencapsulated probiotic yogurt formulation to suppress the intestinal inflammation. We assessed its anticancer activity by screening interleukin-1, 6, and 12 (IL-1, 6, 12), secretory levels of tumor necrosis factor-alpha (TNF- ), interferon-gamma (IFN- ), prostaglandin , and thromboxane B2 in the digesta obtained from the duodenum, jejunum, proximal, and distal segments of the ileum of C57BL/6J- /J mice. Formulation-receiving animals showed consistently lower proinflammatory cytokines' levels when compared to control group animals receiving empty alginate-poly-L-lysine-alginate (APA) microcapsules suspended in saline. The concentrations of IL-12 found in serum in control and treatment group animals were significant: pg/mL and pg/mL for control and treatment animals, respectively. We determined a significant change in plasma C-reactive protein: ng/mL in control group and ng/mL in treatment group. Western blots showed a 71% downregulation of cyclooxygenase-2 (COX-2) protein in treatment group animals compared to control. These results point to the possibility of using this yogurt formulation in anticancer therapies, in addition to chronic gut diseases such as Crohn's disease, irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD) thanks to its inflammation lowering properties.
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Citation
Urbanska, Aleksandra Malgorzata, Arghya Paul, Jasmine Bhahena, and Satya Prakash. "Suppression of Tumorigenesis: Modulation of Inflammatory Cytokines by Oral Administration of Microencapsulated Probiotic Yogurt Formulation." International Journal of Inflammation 2010 (2010): 1-10. http://dx.doi.org/10.4061/2010/894972
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Except where otherwise noted, this item's license is described as: Copyright © 2010 Aleksandra Malgorzata Urbanska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.