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dc.contributor.authorEisenberg, Robert S.
dc.contributor.authorLiu, Weishi
dc.date.accessioned2015-03-03T20:05:16Z
dc.date.available2015-03-03T20:05:16Z
dc.date.issued2007-02-01
dc.identifier.citationLiu, Weishi & Eisenberg, Bob. "Poisson–Nernst–Planck Systems for Ion Channels with Permanent Charges." SIAM J. Math. Anal., 38(6), 1932–1966. (35 pages). http://dx.doi.org/10.1137/060657480.en_US
dc.identifier.urihttp://hdl.handle.net/1808/16945
dc.descriptionThis is the published version, also available here: http://dx.doi.org/10.1137/060657480.en_US
dc.description.abstractIonic channels and semiconductor devices use atomic scale structures to control macroscopic flows from one reservoir to another. The one‐dimensional steady‐state Poisson‐Nernst‐Planck (PNP) system is a useful representation of these devices, but experience shows that describing the reservoirs as boundary conditions is difficult. We study the PNP system for two types of ions with three regions of piecewise constant permanent charge, assuming the Debye number is large, because the electric field is so strong compared to diffusion. Reservoirs are represented by the outer regions with permanent charge zero. If the reciprocal of the Debye number is viewed as a singular parameter, the PNP system can be treated as a singularly perturbed system that has two limiting systems: inner and outer systems (termed fast and slow systems in geometric singular perturbation theory). A complete set of integrals for the inner system is presented that provides information for boundary and internal layers. Application of the exchange lemma from geometric singular perturbation theory gives rise to the existence and (local) uniqueness of the solution of the singular boundary value problem near each singular orbit. A set of simultaneous equations appears in the construction of singular orbits. Multiple solutions of such equations in this or similar problems might explain a variety of multiple valued phenomena seen in biological channels, for example, some forms of gating, and might be involved in other more complex behaviors, for example, some kinds of active transport.en_US
dc.publisherSociety for Industrial and Applied Mathematicsen_US
dc.subjectsingular perturbationen_US
dc.subjectboundary layersen_US
dc.subjectinternal layersen_US
dc.titlePoisson–Nernst–Planck Systems for Ion Channels with Permanent Chargesen_US
dc.typeArticle
kusw.kuauthorLiu, Weishi
kusw.kudepartmentMathematicsen_US
dc.identifier.doi10.1137/060657480
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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