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    Microglial Receptor for Advanced Glycation End Product-Dependent Signal Pathway Drives β-Amyloid-Induced Synaptic Depression and Long-Term Depression Impairment in Entorhinal Cortex

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    Yan_et_al_2010.pdf (1.623Mb)
    Issue Date
    2010-08-25
    Author
    Origlia, Nicola
    Bonadonna, Camilla
    Rosellini, Alfredo
    Leznik, Elena
    Arancio, Ottavio
    Yan, Shirley ShiDu
    Domenici, Luciano
    Publisher
    Sociey for Neuroscience
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
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    Abstract
    Overproduction of β-amyloid (Aβ) is a pathologic feature of Alzheimer's disease, leading to cognitive impairment. Here, we investigated the impact of cell-specific receptor for advanced glycation end products (RAGE) on Aβ-induced entorhinal cortex (EC) synaptic dysfunction. We found both a transient depression of basal synaptic transmission and inhibition of long-term depression (LTD) after the application of Aβ in EC slices. Synaptic depression and LTD impairment induced by Aβ were rescued by functional suppression of RAGE. Remarkably, the rescue was only observed in slices from mice expressing a defective form of RAGE targeted to microglia, but not in slices from mice expressing defective RAGE targeted to neurons. Moreover, we found that the inflammatory cytokine IL-1β (interleukin-1β) and stress-activated kinases [p38 MAPK (p38 mitogen-activated protein kinase) and JNK (c-Jun N-terminal kinase)] were significantly altered and involved in RAGE signaling pathways depending on RAGE expression in neuron or microglia. These findings suggest a prominent role of microglial RAGE signaling in Aβ-induced EC synaptic dysfunction.
    Description
    This is the publisher's version, also available electronically from http://www.jneurosci.org/content/30/34/11414
    URI
    http://hdl.handle.net/1808/14811
    DOI
    https://doi.org/10.1523/JNEUROSCI.2127-10.2010
    ISSN
    0270-6475
    Collections
    • Pharmacy Scholarly Works [293]
    Citation
    Origlia, Nicola et al. (2010). Microglial Receptor for Advanced Glycation End Product-Dependent Signal Pathway Drives β-Amyloid-Induced Synaptic Depression and Long-Term Depression Impairment in Entorhinal Cortex. Journal of Neuroscience 30(34):11414-11425. http://www.dx.doi.org/10.1523/JNEUROSCI.2127-10.2010

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    KU Libraries
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    785-864-8983

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    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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