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dc.contributor.authorMartin, Simon H.
dc.contributor.authorDasmahapatra, Kanchon K.
dc.contributor.authorNadeau, Nicola J.
dc.contributor.authorSalazar, Camilo
dc.contributor.authorWalters, James R.
dc.contributor.authorSimpson, Fraser
dc.contributor.authorBlaxter, Mark
dc.contributor.authorManica, Andrea
dc.contributor.authorMallet, James
dc.contributor.authorJiggins, Chris D.
dc.identifier.citationWalters, James R. (2013). Genome-wide evidence for speciation with gene flow in Heliconius butterflies. Genome research 23(11):1817-28.
dc.descriptionThis is the publishers version, also available electronically from
dc.description.abstractMost speciation events probably occur gradually, without complete and immediate reproductive isolation, but the full extent of gene flow between diverging species has rarely been characterized on a genome-wide scale. Documenting the extent and timing of admixture between diverging species can clarify the role of geographic isolation in speciation. Here we use new methodology to quantify admixture at different stages of divergence in Heliconius butterflies, based on whole-genome sequences of 31 individuals. Comparisons between sympatric and allopatric populations of H. melpomene, H. cydno, and H. timareta revealed a genome-wide trend of increased shared variation in sympatry, indicative of pervasive interspecific gene flow. Up to 40% of 100-kb genomic windows clustered by geography rather than by species, demonstrating that a very substantial fraction of the genome has been shared between sympatric species. Analyses of genetic variation shared over different time intervals suggested that admixture between these species has continued since early in speciation. Alleles shared between species during recent time intervals displayed higher levels of linkage disequilibrium than those shared over longer time intervals, suggesting that this admixture took place at multiple points during divergence and is probably ongoing. The signal of admixture was significantly reduced around loci controlling divergent wing patterns, as well as throughout the Z chromosome, consistent with strong selection for Müllerian mimicry and with known Z-linked hybrid incompatibility. Overall these results show that species divergence can occur in the face of persistent and genome-wide admixture over long periods of time.
dc.publisherCold Spring Harbor Laboratory Press
dc.rightsThis article is being made available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported)
dc.titleGenome-wide evidence for speciation with gene flow in Heliconius butterflies
kusw.kuauthorWalters, James R.
kusw.kudepartmentEcology & Evolutionary Biology
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.

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This article is being made available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported)
Except where otherwise noted, this item's license is described as: This article is being made available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported)