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dc.contributor.authorChattopadhyay, Kalicharan
dc.contributor.authorFenster, Erik
dc.contributor.authorGrenning, Alexander J.
dc.contributor.authorTunge, Jon A.
dc.date.accessioned2014-04-17T21:05:33Z
dc.date.available2014-04-17T21:05:33Z
dc.date.issued2012-07-27
dc.identifier.citationChattopadhyay, Kalicharan, Erik Fenster, Alexander J Grenning, and Jon A Tunge. 2012. “Palladium-Catalyzed Substitution of (coumarinyl)methyl Acetates with C-, N-, and S-Nucleophiles.” Beilstein Journal of Organic Chemistry 8 : 1200–1207. http://dx.doi.org/10.3762/bjoc.8.133
dc.identifier.urihttp://hdl.handle.net/1808/13551
dc.description.abstractThe palladium-catalyzed nucleophilic substitution of (coumarinyl)methyl acetates is described. The reaction proceeds though a palladium π-benzyl-like complex and allows for many different types of C-, N-, and S-nucleophiles to be regioselectively added to the biologically active coumarin motif. This new method was utilized to prepare a 128-membered library of aminated coumarins for biological screening.
dc.description.sponsorshipWe thank the National Institutes of Health KU Chemical Methodologies and Library Development Center of Excellence (P50 GM069663) for funding. We are indebted to Dr. Conrad Santini and Ben Neuenswander for help in library production and purification.
dc.publisherBeilstein-Institut
dc.rightsThis is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)
dc.rights.urihttp://creativecommons.org/licenses/by/2.0
dc.subjectBenzylation
dc.subjectCatalysis
dc.subjectCourmarin
dc.subjectChemical Diversity
dc.subjectDecarboxylative
dc.subjectPalladium
dc.subjectSubstitution
dc.titlePalladium-catalyzed substitution of (coumarinyl)methyl acetates with C-, N-, and S-nucleophiles
dc.typeArticle
kusw.kuauthorChattopadhyay, Kalicharan
kusw.kuauthorFenster, Erik
kusw.kuauthorGrenning, Alexander J.
kusw.kuauthorTunge, Jon A.
kusw.kudepartmentDepartment of Chemistry
kusw.oastatusfullparticipation
dc.identifier.doi10.3762/bjoc.8.133
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)
Except where otherwise noted, this item's license is described as: This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)