Palladium-catalyzed substitution of (coumarinyl)methyl acetates with C-, N-, and S-nucleophiles
dc.contributor.author | Chattopadhyay, Kalicharan | |
dc.contributor.author | Fenster, Erik | |
dc.contributor.author | Grenning, Alexander J. | |
dc.contributor.author | Tunge, Jon A. | |
dc.date.accessioned | 2014-04-17T21:05:33Z | |
dc.date.available | 2014-04-17T21:05:33Z | |
dc.date.issued | 2012-07-27 | |
dc.identifier.citation | Chattopadhyay, Kalicharan, Erik Fenster, Alexander J Grenning, and Jon A Tunge. 2012. “Palladium-Catalyzed Substitution of (coumarinyl)methyl Acetates with C-, N-, and S-Nucleophiles.” Beilstein Journal of Organic Chemistry 8 : 1200–1207. http://dx.doi.org/10.3762/bjoc.8.133 | |
dc.identifier.uri | http://hdl.handle.net/1808/13551 | |
dc.description.abstract | The palladium-catalyzed nucleophilic substitution of (coumarinyl)methyl acetates is described. The reaction proceeds though a palladium π-benzyl-like complex and allows for many different types of C-, N-, and S-nucleophiles to be regioselectively added to the biologically active coumarin motif. This new method was utilized to prepare a 128-membered library of aminated coumarins for biological screening. | |
dc.description.sponsorship | We thank the National Institutes of Health KU Chemical Methodologies and Library Development Center of Excellence (P50 GM069663) for funding. We are indebted to Dr. Conrad Santini and Ben Neuenswander for help in library production and purification. | |
dc.publisher | Beilstein-Institut | |
dc.rights | This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc) | |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0 | |
dc.subject | Benzylation | |
dc.subject | Catalysis | |
dc.subject | Courmarin | |
dc.subject | Chemical Diversity | |
dc.subject | Decarboxylative | |
dc.subject | Palladium | |
dc.subject | Substitution | |
dc.title | Palladium-catalyzed substitution of (coumarinyl)methyl acetates with C-, N-, and S-nucleophiles | |
dc.type | Article | |
kusw.kuauthor | Chattopadhyay, Kalicharan | |
kusw.kuauthor | Fenster, Erik | |
kusw.kuauthor | Grenning, Alexander J. | |
kusw.kuauthor | Tunge, Jon A. | |
kusw.kudepartment | Department of Chemistry | |
kusw.oastatus | fullparticipation | |
dc.identifier.doi | 10.3762/bjoc.8.133 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |
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Except where otherwise noted, this item's license is described as: This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)