| dc.contributor.author | Struckhoff, Eric Charles | |
| dc.contributor.author | Lundquist, Erik A. | |
| dc.date.accessioned | 2007-04-04T21:11:10Z | |
| dc.date.available | 2007-04-04T21:11:10Z | |
| dc.date.issued | 2003-02 | |
| dc.identifier.citation | Struckhoff, EC; Lundquist, EA. The actin-binding protein UNC-115 is an effector of Rac signaling during axon pathfinding in C-elegans. DEVELOPMENT. FEB 2003. 130(4) : 693-704. | |
| dc.identifier.uri | http://hdl.handle.net/1808/1269 | |
| dc.description.abstract | Rac GTPases control cell shape by regulating downstream effectors that influence the actin cytoskeleton. UNC-115, a putative actin-binding protein similar to human abLIM/limatin, has previously been implicated in axon pathfinding. We have discovered the role of UNC-115 as a downstream cytoskeletal effector of Rac signaling in axon pathfinding. We show that unc-115 double mutants with ced-10 Rac, mig-2 Rac or unc-73 GEF but not with rac-2/3 Rac displayed synthetic axon pathfinding defects, and that loss of unc-115 function suppressed the formation of ectopic plasma membrane extensions induced by constitutively-active rac-2 in neurons. Furthermore, we show that UNC-115 can bind to actin filaments. Thus, UNC-115 is an actin-binding protein that acts downstream of Rac signaling in axon pathfinding. | |
| dc.language.iso | en_US | |
| dc.publisher | COMPANY OF BIOLOGISTS LTD | |
| dc.subject | Rac | |
| dc.subject | UNC-115 | |
| dc.subject | Actin-binding protein | |
| dc.subject | Axon pathfinding | |
| dc.title | The actin-binding protein UNC-115 is an effector of Rac signaling during axon pathfinding in C-elegans | |
| dc.type | Article | |
| kusw.kuauthor | Lundquist, Erik A. | |
| dc.rights.accessrights | openAccess | |
