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Direct reductive coupling of indoles to nitrostyrenes en route to (indol-3-yl)acetamides
Aksenov, Alexander V. Aksenov, Nicolai A. Dzhandigova, Zarema V. Aksenov, Dmitrii A. Voskressensky, Leonid G. Nenajdenko, Valentine G. Rubin, Michael
Aksenov, Alexander V.
Aksenov, Nicolai A.
Dzhandigova, Zarema V.
Aksenov, Dmitrii A.
Voskressensky, Leonid G.
Nenajdenko, Valentine G.
Rubin, Michael
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Abstract
A highly efficient one-pot method for the reductive coupling of indoles to nitrostyrenes in polyphosphoric acid doped with PCl3 was developed. This method allows direct and expeditious access to primary (indol-3-yl)acetamides, interesting as anti-cancer drug candidates.
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2016-09-27
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Royal Society of Chemistry
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Aksenov, A. V., Aksenov, N. A., Dzhandigova, Z. V., Aksenov, D. A., Voskressensky, L. G., Nenajdenko, V. G., & Rubin, M. (2016). Direct reductive coupling of indoles to nitrostyrenes en route to (indol-3-yl)acetamides. RSC Advances, 6(96), 93881-93886. doi:10.1039/c6ra21399e