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Potential mammalian filovirus reservoirs
Peterson, A. Townsend Carroll, Darin S. Mills, James N. Johnson, Karl M.
Peterson, A. Townsend
Carroll, Darin S.
Mills, James N.
Johnson, Karl M.
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Abstract
Ebola and Marburg viruses are maintained in unknown
reservoir species; spillover into human populations results
in occasional human cases or epidemics. We attempted to
narrow the list of possibilities regarding the identity of those
reservoir species. We made a series of explicit assumptions
about the reservoir: it is a mammal; it supports persistent,
largely asymptomatic filovirus infections; its range
subsumes that of its associated filovirus; it has coevolved
with the virus; it is of small body size; and it is not a species
that is commensal with humans. Under these assumptions,
we developed priority lists of mammal clades that coincide
distributionally with filovirus outbreak distributions and
compared these lists with those mammal taxa that have
been tested for filovirus infection in previous epidemiologic
studies. Studying the remainder of these taxa may be a
fruitful avenue for pursuing the identity of natural reservoirs
of filoviruses.
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Centers for Disease Control and Prevention
http://www.cdc.gov/ncidod/EID/vol10no12/04-0346.htm
Date
2004-12
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Centers for Disease Control and Prevention
Research Projects
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Citation
Peterson, A. T., D. Carroll, and J. N. Mills. 2004. Potential mammalian filovirus reservoirs. Emerging Infectious Diseases 10:2073-2081.