Loading...
Oxidative Cyclization of 4-(2-Aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-Oxoindolin-2-ylidene)acetonitriles
Aksenov, Nicolai A. Aksenov, Alexander V. Prityko, Lidiya A. Aksenov, Dmitrii A. Aksenova, Daria S. Nobi, Mezvah A. Rubin, Michael
Aksenov, Nicolai A.
Aksenov, Alexander V.
Prityko, Lidiya A.
Aksenov, Dmitrii A.
Aksenova, Daria S.
Nobi, Mezvah A.
Rubin, Michael
Citations
Altmetric:
Abstract
A facile and highly efficient method for the preparation of 2-(3-oxoindolin-2-ylidene)acetonitriles from 4-(2-aminophenyl)-4-oxo-2-phenylbutanenitriles is described. The featured transformation operates via nucleophilic intramolecular cyclization and involves oxidation of the aniline moiety. Overall, this modification allowed for the improvement of yields and expansion of the reaction scope.
Description
Date
2022-04-15
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
Collections
Research Projects
Organizational Units
Journal Issue
Keywords
Citation
Aksenov NA, Aksenov AV, Prityko LA, Aksenov DA, Aksenova DS, Nobi MA, Rubin M. Oxidative Cyclization of 4-(2-Aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-Oxoindolin-2-ylidene)acetonitriles. ACS Omega. 2022 Apr 15;7(16):14345-14356. doi: 10.1021/acsomega.2c01238. PMID: 35573208; PMCID: PMC9089741.