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Copper-Catalyzed Decarboxylative Trifluoromethylation of Allylic Bromodifluoroacetates
Ambler, Brett R. Altman, Ryan A.
Ambler, Brett R.
Altman, Ryan A.
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Abstract
The development of new synthetic fluorination reactions has important implications in medicinal, agricultural and materials chemistries. Given the prevalence and accessibility of alcohols, methods to convert alcohols to trifluoromethanes are desirable. However, this transformation typically requires four-step processes, specialty chemicals, and/or stoichiometric metals to access the trifluoromethyl-containing product. A two-step copper-catalyzed decarboxylative protocol for converting allylic alcohols to trifluoromethanes is reported. Preliminary mechanistic studies distinguish this reaction from previously reported Cu-mediated reactions.
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2013-11
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American Chemical Society
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Ambler, B. R., & Altman, R. A. (2013). Copper-Catalyzed Decarboxylative Trifluoromethylation of Allylic Bromodifluoroacetates. Organic Letters, 15(21), 10.1021/ol402780k. http://doi.org/10.1021/ol402780k