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Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin
Guo, Chun-Jun Knox, Benjamin P. Chiang, Yi-Ming Lo, Hsien-Chun Sanchez, James F. Lee, Kuan-Han Oakley, Berl R. Bruno, Kenneth S. Wang, Clay C. C.
Guo, Chun-Jun
Knox, Benjamin P.
Chiang, Yi-Ming
Lo, Hsien-Chun
Sanchez, James F.
Lee, Kuan-Han
Oakley, Berl R.
Bruno, Kenneth S.
Wang, Clay C. C.
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Abstract
Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.
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2012-11-16
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American Chemical Society
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Guo, C.-J., Knox, B. P., Chiang, Y.-M., Lo, H.-C., Sanchez, J. F., Lee, K.-H., … Wang, C. C. C. (2012). Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin. Organic Letters, 14(22), 5684–5687. http://doi.org/10.1021/ol302682z