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Remodeler Catalyzed Nucleosome Repositioning: Influence of Structure and Stability

Morgan, Aaron
; 
LeGresley, Sarah
; 
Fischer, Christopher
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Abstract
The packaging of the eukaryotic genome into chromatin regulates the storage of genetic information, including the access of the cell’s DNA metabolism machinery. Indeed, since the processes of DNA replication, translation, and repair require access to the underlying DNA, several mechanisms, both active and passive, have evolved by which chromatin structure can be regulated and modified. One mechanism relies upon the function of chromatin remodeling enzymes which couple the free energy obtained from the binding and hydrolysis of ATP to the mechanical work of repositioning and rearranging nucleosomes. Here, we review recent work on the nucleosome mobilization activity of this essential family of molecular machines.
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Date
2020-12-23
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MDPI
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Physics & Astronomy Scholarly Works
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Keywords
Chromatin remodelers, Nucleosome repositioning, Molecular machines, Enzyme mechanism
Citation
Morgan, A.; LeGresley, S.; Fischer, C. Remodeler Catalyzed Nucleosome Repositioning: Influence of Structure and Stability. Int. J. Mol. Sci. 2021, 22, 76. https://doi.org/10.3390/ijms22010076
URI
https://hdl.handle.net/1808/32392
DOI
10.3390/ijms22010076
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