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Metathesis Cascade Strategies (ROM-RCM-CM): A DOS approach to Skeletally Diverse Sultams
Jeon, Kyu Ok Rayabarapu, Dinesh Kumar Rolfe, Alan Volp, Kelly Omar, Iman Hanson, Paul R.
Jeon, Kyu Ok
Rayabarapu, Dinesh Kumar
Rolfe, Alan
Volp, Kelly
Omar, Iman
Hanson, Paul R.
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Abstract
The development of a ring-opening metathesis/ring-closing metathesis/cross metathesis (ROM-RCM-CM) cascade strategy to the synthesis of a diverse collection of bi- and tricyclic sultams is reported. In this study, functionalized sultam scaffolds derived from intramolecular Diels-Alder (IMDA) reactions undergo metathesis cascades to yield a collection tricyclic sultams. Additional appendage based diversity was achieved by utilizing a variety of CM partners.
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Date
2009-06-27
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Elsevier
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Keywords
Cascade, Sultam, RCM, DOS
Citation
Jeon, Kyu Ok et al. “Metathesis Cascade Strategies (ROM-RCM-CM): A DOS Approach to Skeletally Diverse Sultams.” Tetrahedron 65.26 (2009): 4992–5000.