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Photoacoustic detection of functional responses in the motor cortex of awake behaving monkey during forelimb movement
Jo, Janggun Zhang, Hongyu Cheney, Paul D. Yang, Xinmai
Jo, Janggun
Zhang, Hongyu
Cheney, Paul D.
Yang, Xinmai
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Abstract
Photoacoustic (PA) imaging was applied to detect the neuronal activity in the motor cortex of an awake, behaving monkey during forelimb movement. An adult macaque monkey was trained to perform a reach-to-grasp task while PA images were acquired through a 30-mm diameter implanted cranial chamber. Increased PA signal amplitude results from an increase in regional blood volume and is interpreted as increased neuronal activity. Additionally, depth-resolved PA signals enabled the study of functional responses in deep cortical areas. The results demonstrate the feasibility of utilizing PA imaging for studies of functional activation of cerebral cortex in awake monkeys performing behavioral tasks.
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This is the published version. Copyright 2012 Society of Photo-optical Instrumentation Engineers
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2012-10-22
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Society of Photo-optical Instrumentation Engineers
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Xinmai_cortex2012.pdf
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Jo, Janggun, Hongyu Zhang, Paul D. Cheney, and Xinmai Yang. "Photoacoustic Detection of Functional Responses in the Motor Cortex of Awake Behaving Monkey during Forelimb Movement." J. Biomed. Opt Journal of Biomedical Optics 17.11 (2012): 110503. http://dx.doi.org/10.1117/1.JBO.17.11.110503