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Bioactivity Profiling of Plant Biodiversity of Panama by High Throughput Screening
Roy, Anuradha McDonald, Peter Timmermann, Barbara N. Gupta, Mahabir Chaguturu, Rathnam
Roy, Anuradha
McDonald, Peter
Timmermann, Barbara N.
Gupta, Mahabir
Chaguturu, Rathnam
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Abstract
We report relative bioactivities of extracts prepared from a large collection of plants from three national parks in Panama. Over 181 plants were collected, taxonomically identified and their detannified dichloromethane (DCM)-methanolic extracts were used for profiling selected bioactivities. Assays were performed to evaluate the antioxidant activity of the extracts for Antioxidant Response Element (ARE) induction, total non-enzymatic antioxidant potential, anti-inflammatory and anticancer properties. The high throughput analysis of 280 extracts resulted in identification of 57.5% of the extracts that could induce ARE at one or more concentrations tested, 93.5% that harbored total antioxidant capacity, and 2.1% of the extracts that showed lung cancer cell line-specific cytotoxicity. Data from our profiling experiments indicate that a large number of extracts could be a source for further isolation and chemical identification of compounds that could serve as leads for discovery of antioxidant, anticancer and anti-inflammatory agents to prevent or treat complex diseases like cancer and neurodegenerative disorders.
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Date
2019-01-01
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SAGE Publications
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Keywords
Bioprospection, Plants, Panama, Biomedicine, Screening, Cancer, Alzheimer, Anti-inflammation, Total Antioxidant Capacity, Antioxidant Response Element, Cytotoxicity, IL-2
Citation
Roy, A., McDonald, P., Timmermann, B. N., Gupta, M., & Chaguturu, R. (2019). Bioactivity Profiling of Plant Biodiversity of Panama by High Throughput Screening. Natural product communications, 14(1), 71–74. https://doi.org/10.1177/1934578X1901400119