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Action of Pyrroloquinolinequinol As an Antioxidant Against Lipid Peroxidation in Solution
Miyauchi, Kazuhiro Urakami, Teiji Abeta, Hiroyuki Shi, Honglian Noguchi, Noriko Niki, Etsuo
Miyauchi, Kazuhiro
Urakami, Teiji
Abeta, Hiroyuki
Shi, Honglian
Noguchi, Noriko
Niki, Etsuo
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Abstract
The activities of pyrroloquinoline quinone (PQQ), a coenzyme of methanol dehydrogenase and amine oxidase,
and its reduced form pyrroloquinoline quinol (PQQH2 ) as an antioxidant have been measured in solution. PQQH2
was stable in the absence of oxygen but rapidly auto-oxidized to PQQ in the presence of oxygen in water. PQQH2
was stable in an aprotic solvent such as acetonitrile, even in air. PQQ did not exert appreciable antioxidant activity,
whereas PQQH2 exerted higher reactivity than a-tocopherol toward galvinoxyl radical and peroxyl radical.
PQQH2 acted as a potent antioxidant against the oxidation of methyl linoleate in acetonitrile induced by azo compound
and produced a clear induction period, from which the apparent stoichiometric number was obtained as
1.1. PQQH2 reduced the a-tocopheroxyl radical and spared a-tocopherol in the oxidation of methyl linoleate. These
results suggest that PQQH2 may act as a potent antioxidant, particularly in combination with a-tocopherol. Antiox.
Redox Signal. 1, 547-554.
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This is the publisher's version, also available electronically from: http://online.liebertpub.com/doi/pdfplus/10.1089/ars.1999.1.4-547.
Date
1999
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Mary Ann Liebert
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Miyauchi K, Urakami T, Abeta H, Shi H, Noguchi N, and Niki E. Action of pyrroloquinolinequinol as an antioxidant against lipid peroxidation in solution. Antioxidants & Redox Signaling 1: 547-554; http://online.liebertpub.com/doi/pdfplus/10.1089/ars.1999.1.4-547