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Quantitative in vivo measurement of early axonal transport deficits in a triple transgenic mouse model of Alzheimer’s disease using manganese-enhanced MRI
Kim, Jieun Choi, In-Young Michaelis, Mary Lou Lee, Phil
Kim, Jieun
Choi, In-Young
Michaelis, Mary Lou
Lee, Phil
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Abstract
Impaired axonal transport has been linked to the pathogenic processes of Alzheimer’s disease (AD) in which axonal swelling and degeneration are prevalent. The development of non-invasive neuroimaging methods to quantitatively assess in vivo axonal transport deficits would be enormously valuable to visualize early, yet subtle, changes in the AD brain, to monitor the disease progression and to quantify the effect of drug intervention. A triple transgenic mouse model of AD closely resembles human AD neuropathology. In this study, we investigated age-dependent alterations in the axonal transport rate in a longitudinal assessment of the triple transgenic mouse olfactory system, using fast multi-sliced T1 mapping with manganese-enhanced MRI. The data show that impairment in axonal transport is a very early event in AD pathology in these mice, preceding both deposition of Aβ plaques and formation of Tau fibrils.
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Date
2011-06-01
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Elsevier
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Keywords
Axonal transport, Alzheimer’s disease, MEMRI, Triple transgenic mouse model, T1 mapping
Citation
Kim, J., Choi, I.-Y., Michaelis, M. L., & Lee, P. (2011). Quantitative in vivo measurement of early axonal transport deficits in a triple transgenic mouse model of Alzheimer’s disease using manganese-enhanced MRI. NeuroImage, 56(3), 1286–1292. http://doi.org/10.1016/j.neuroimage.2011.02.039