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Intramyocardial sustained delivery of placental growth factor using nanoparticles as a vehicle for delivery in the rat infarct model
Binsalamah, Ziyad Mohammed Paul, Arghya Khan, Afshan Afsar Prakash, Satya Shum-Tim, Dominique
Binsalamah, Ziyad Mohammed
Paul, Arghya
Khan, Afshan Afsar
Prakash, Satya
Shum-Tim, Dominique
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Abstract
Acute myocardial ischemia results in scar formation with ventricular dilatation and eventually heart failure. Placental growth factor (PlGF) is reported to stimulate angiogenesis and improve cardiac function. In this study, it was hypothesized that intramyocardial injection of PlGF contained in nanoparticles can be released at the site of action for an extended time period as a sustained slow-release protective mechanism that accelerates myocardial recovery in a rat model of ischemic cardiomyopathy.
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Date
2011-10-31
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Publisher
Dove Medical Press
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Keywords
Nanotechnology, Serum cytokines, Myocardial therapy, Angiogenesis, Regenerative medicine
Citation
Shum-Tim, Dominique, Arghya Paul, Afshan Afsar Khan, Satya Prakash, and Dominique Shum-Tim. "Intramyocardial Sustained Delivery of Placental Growth Factor Using Nanoparticles as a Vehicle for Delivery in the Rat Infarct Model." International Journal of Nanomedicine IJN (2011): 2667. http://dx.doi.org/10.2147/IJN.S25175