Loading...
Interaction of Shigella flexneri IpaC with Model Membranes Correlates with Effects on Cultured Cells
Tran, Ngoc Barnoski Serfis, Alexa Osiecki, John C. Picking, Wendy Lynn Coye, Lisette Davis, Rebecca Picking, William D.
Tran, Ngoc
Barnoski Serfis, Alexa
Osiecki, John C.
Picking, Wendy Lynn
Coye, Lisette
Davis, Rebecca
Picking, William D.
Citations
Altmetric:
Abstract
Invasion of enterocytes by Shigella flexneri requires the properly timed release of IpaB and IpaC at the host-pathogen interface; however, only IpaC has been found to possess quantifiable activities in vitro. We demonstrate here that when added to cultured cells, purified IpaC elicits cytoskeletal changes similar to those that occur during Shigella invasion. This IpaC effect may correlate with its ability to interact with model membranes at physiological pH and to promote entry by an ipaC mutant of S. flexneri.
Description
Date
2000-06
Journal Title
Journal ISSN
Volume Title
Publisher
American Society for Microbiology
Collections
Research Projects
Organizational Units
Journal Issue
Keywords
Citation
Tran, N., Serfis, A. B., Osiecki, J. C., Picking, W. L., Coye, L., Davis, R., & Picking, W. D. (2000). Interaction of Shigella flexneri IpaC with Model Membranes Correlates with Effects on Cultured Cells. Infection and Immunity, 68(6), 3710–3715.