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Limits to the generalizability of resting-state functional magnetic resonance imaging studies of youth: An examination of ABCD Study® baseline data
Cosgrove, Kelly T. McDermott, Timothy J. White, Evan J. Mosconi, Matthew W. Thompson, Wesley K. Paulus, Martin P. Cardenas-Iniguez, Carlos Aupperle, Robin L.
Cosgrove, Kelly T.
McDermott, Timothy J.
White, Evan J.
Mosconi, Matthew W.
Thompson, Wesley K.
Paulus, Martin P.
Cardenas-Iniguez, Carlos
Aupperle, Robin L.
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Abstract
This study examined how resting-state functional magnetic resonance imaging (rs-fMRI) data quality and availability relate to clinical and sociodemographic variables within the Adolescent Brain Cognitive Development Study. A sample of participants with an adequate sample of quality baseline rs-fMRI data containing low average motion (framewise displacement ≤ 0.15; low-noise; n = 4,356) was compared to a sample of participants without an adequate sample of quality data and/or containing high average motion (higher-noise; n = 7,437) using Chi-squared analyses and t-tests. A linear mixed model examined relationships between clinical and sociodemographic characteristics and average head motion in the sample with low-noise data. Relative to the sample with higher-noise data, the low-noise sample included more females, youth identified by parents as non-Hispanic white, and youth with married parents, higher parent education, and greater household incomes (ORs = 1.32–1.42). Youth in the low-noise sample were also older and had higher neurocognitive skills, lower BMIs, and fewer externalizing and neurodevelopmental problems (ds = 0.12–0.30). Within the low-noise sample, several clinical and demographic characteristics related to motion. Thus, participants with low-noise rs-fMRI data may be less representative of the general population and motion may remain a confound in this sample. Future rs-fMRI studies of youth should consider these limitations in the design and analysis stages in order to optimize the representativeness and clinical relevance of analyses and results.
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Date
2022-05-12
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Springer
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Keywords
ABCD Study, Resting-state fMRI, Head motion, Sociodemographic factors, Generalizability
Citation
Cosgrove, K.T., McDermott, T.J., White, E.J. et al. Limits to the generalizability of resting-state functional magnetic resonance imaging studies of youth: An examination of ABCD Study® baseline data. Brain Imaging and Behavior 16, 1919–1925 (2022). https://doi.org/10.1007/s11682-022-00665-2