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Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology
Caylor, Raymond Clinton ; Jin, Yishi ; Ackley, Brian D.
Caylor, Raymond Clinton
Jin, Yishi
Ackley, Brian D.
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Abstract
The conserved Caenorhabditis elegans proteins NID-1/nidogen and PTP-3A/LAR-RPTP function to
efficiently localize the presynaptic scaffold protein SYD-2/α-liprin at active zones. Loss of function in these
molecules results in defects in the size, morphology and spacing of neuromuscular junctions.
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Date
2013-01-01
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BioMed Central
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Keywords
Calcium channels, Synaptogenesis, Extracellular matrix, Nidogen, LAR-RPTP, a-liprin, Cell adhesion
Citation
Caylor, Raymond C, Yishi Jin, and Brian D Ackley. 2013. “The Caenorhabditis Elegans Voltage-Gated Calcium Channel Subunits UNC-2 and UNC-36 and the Calcium-Dependent Kinase UNC-43/CaMKII Regulate Neuromuscular Junction Morphology.” Neural Development 8: 10. http://dx.doi.org/10.1186/1749-8104-8-10