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Effects of nanomaterial physicochemical properties on in vivo toxicity
Aillon, Kristin L. Xie, Yumei El-Gendy, Nashwa Berkland, Cory J. Forrest, M. Laird
Aillon, Kristin L.
Xie, Yumei
El-Gendy, Nashwa
Berkland, Cory J.
Forrest, M. Laird
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Abstract
It is well recognized that physical and chemical properties of materials can alter dramatically at nanoscopic scale, and the growing use of nanotechnologies requires careful assessment of unexpected toxicities and biological interactions. However, most in vivo toxicity concerns focus primarily on pulmonary, oral, and dermal exposure to ultrafine particles. As nanomaterials expand as therapeutics and as diagnostic tools, parenteral administration of engineered nanomaterials should also be recognized as a critical aspect for toxicity consideration. Due to the complex nature of nanomaterials, conflicting studies have led to different views of their safety. Here, the physicochemical properties of four representative nanomaterials (dendrimers, carbon nanotubes, quantum dots, and gold nanoparticles) as it relates to their toxicity after systemic exposure is discussed.
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Date
2010-06-21
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Publisher
Elsevier
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Keywords
Nanomaterial, Toxicity, In vivo, Dendrimer, Carbon nanotube, Quantum dot, Gold nanoparticle, Analysis
Citation
Aillon, Kristin L., Yumei Xie, Nashwa El-Gendy, Cory J. Berkland, and M. Laird Forrest. "Effects of Nanomaterial Physicochemical Properties on in Vivo Toxicity." Advanced Drug Delivery Reviews 61.6 (2009): 457-66.