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New insights from animal models of colon cancer: inflammation control as a new facet on the tumor suppressor APC gem
Zeineldin, Maged Neufeld, Kristi L.
Zeineldin, Maged
Neufeld, Kristi L.
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Abstract
Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths worldwide. As with other cancers, CRC is a genetic disease, however, several risk factors including diet and chronic colitis predispose to the disease. Mutations in the tumor suppressor adenomatous polyposis coli (APC) initiate most cases of CRC. Recent data from mouse models suggest that APC mutations and colitis are not completely independent factors in colorectal carcinogenesis. Here, we review the evidence supporting an interaction between APC mutations and chronic colitis. We will also discuss possible pathophysiologic mechanisms behind this interaction.
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This is the published version. Copyright 2015 Dove Medical Press.
Date
2015-01-30
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Dove Medical Press
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Keywords
rodent model, colon cancer, adenomatous polyposis coli, APC, tumor suppressor, inflammatory bowel disease
Citation
Neufeld, Kristi, and Maged Zeineldin. "New Insights from Animal Models of Colon Cancer: Inflammation Control as a New Facet on the Tumor Suppressor APC Gem." GICTT Gastrointestinal Cancer: Targets and Therapy (2015): 39. http://dx.doi.org/10.2147/GICTT.S51386.