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The L-DBF vaccine cross protects mice against different serotypes after prior exposure to the pathogen
Picking, Wendy L
Picking, Wendy L
Abstract
Shigellosis is endemic to low- and middle-income regions of the world where children are especially vulnerable. In many cases, there are pre-existing antibodies in the local population and the effect of prior exposure should be considered in the development and testing of vaccines against infection. Our study shows that L-DBF-induced immune responses are not adversely affected by prior exposure to this pathogen. Moreover, somewhat different cytokine profiles were observed in the lungs of vaccinated mice not having been exposed to , suggesting that the immune responses elicited by infection and L-DBF vaccination follow different pathways.
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2023-12-12
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American Society for Microbiology
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spectrum.00062-23.pdf
Adobe PDF, 1.55 MB
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vaccine
Citation
Lu T, Howlader DR, Das S, Dietz ZK, Nagel AC, Whittier SK, Picking WD, Picking WL. The L-DBF vaccine cross protects mice against different Shigella serotypes after prior exposure to the pathogen. Microbiol Spectr. 2023 Dec 12;11(6):e0006223. doi: 10.1128/spectrum.00062-23. Epub 2023 Oct 3. PMID: 37787548; PMCID: PMC10714971