A Phosphate Tether-Mediated, One-pot, Sequential RCM/CM/Chemo-selective Hydrogenation Protocol
Venukadasula, Phanindra K. M. Chegondi, Rambabu Suryn, Gregory M. Hanson, Paul R.
Venukadasula, Phanindra K. M.
Chegondi, Rambabu
Suryn, Gregory M.
Hanson, Paul R.
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Abstract
A versatile three-step, one-pot, sequential reaction protocol involving RCM, CM, and chemoselective hydrogenation is reported. This phosphate tether-mediated process occurs without intermediate isolation, is chemoselective and is governed by stereoelectronic properties innate to phosphate tethers, which ultimately act to preserve the integrity of the bisallylic, bicyclic phosphate for subsequent nucleophilic additions. Overall, this process can be used to efficiently generate advanced polyol synthons.
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2012-05-18
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American Chemical Society
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Venukadasula, P. K. M., Chegondi, R., Suryn, G. M., & Hanson, P. R. (2012). A Phosphate Tether-Mediated, One-pot, Sequential RCM/CM/Chemo-selective Hydrogenation Protocol. Organic Letters, 14(10), 2634–2637. http://doi.org/10.1021/ol301007h