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MicroRNA Expression can be a Promising Strategy for the Detection of Barrett's Esophagus: A Pilot Study

Bansal, Ajay
Hong, Xiaoman
Lee, In-Hee
Krishnadath, Kausilia K.
Mathur, Sharad C.
Gunewardena, Sumedha
Rastogi, Amit
Sharma, Prateek
Christenson, Lane K.
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Abstract
Patient outcomes for esophageal adenocarcinoma (EAC) have not improved despite huge advances in endoscopic therapy because cancers are being diagnosed late. Barrett's esophagus (BE) is the primary precursor lesion for EAC, and thus the non-endoscopic molecular diagnosis of BE can be an important approach to improve EAC outcomes if robust biomarkers for timely diagnosis are identified. MicroRNAs (miRNAs) are tissue-specific novel biomarkers that regulate gene expression and may satisfy this requirement.
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Clinical and Translational Gastroenterology is an open-access journal published by Nature Publishing Group.
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2014-12-11
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Nature Publishing Group
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Bansal et al. "MicroRNA Expression can be a Promising Strategy for the Detection of Barrett's Esophagus: A Pilot Study." Clin Transl Gastroenterol. Dec 2014; 5(12): e65. http://dx.doi.org/10.1038/ctg.2014.17
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