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Suppression of Tumorigenesis: Modulation of Inflammatory Cytokines by Oral Administration of Microencapsulated Probiotic Yogurt Formulation
Urbanska, Aleksandra Malgorzata Paul, Arghya Bhahena, Jasmine Prakash, Satya
Urbanska, Aleksandra Malgorzata
Paul, Arghya
Bhahena, Jasmine
Prakash, Satya
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Abstract
The objective of this study was to examine the ability of a novel microencapsulated probiotic yogurt formulation to suppress the intestinal inflammation. We assessed its anticancer activity by screening interleukin-1, 6, and 12 (IL-1, 6, 12), secretory levels of tumor necrosis factor-alpha (TNF- ), interferon-gamma (IFN- ), prostaglandin , and thromboxane B2 in the digesta obtained from the duodenum, jejunum, proximal, and distal segments of the ileum of C57BL/6J- /J mice. Formulation-receiving animals showed consistently lower proinflammatory cytokines' levels when compared to control group animals receiving empty alginate-poly-L-lysine-alginate (APA) microcapsules suspended in saline. The concentrations of IL-12 found in serum in control and treatment group animals were significant: pg/mL and pg/mL for control and treatment animals, respectively. We determined a significant change in plasma C-reactive protein: ng/mL in control group and ng/mL in treatment group. Western blots showed a 71% downregulation of cyclooxygenase-2 (COX-2) protein in treatment group animals compared to control. These results point to the possibility of using this yogurt formulation in anticancer therapies, in addition to chronic gut diseases such as Crohn's disease, irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD) thanks to its inflammation lowering properties.
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2010-08
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Hindawi Publishing Corporation
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Urbanska, Aleksandra Malgorzata, Arghya Paul, Jasmine Bhahena, and Satya Prakash. "Suppression of Tumorigenesis: Modulation of Inflammatory Cytokines by Oral Administration of Microencapsulated Probiotic Yogurt Formulation." International Journal of Inflammation 2010 (2010): 1-10. http://dx.doi.org/10.4061/2010/894972