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Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease
Jia, Kun Du, Heng
Jia, Kun
Du, Heng
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Abstract
Advanced age is the greatest risk factor for aging-related brain disorders including Alzheimer’s disease (AD). However, the detailed mechanisms that mechanistically link aging and AD remain elusive. In recent years, a mitochondrial hypothesis of brain aging and AD has been accentuated. Mitochondrial permeability transition pore (mPTP) is a mitochondrial response to intramitochondrial and intracellular stresses. mPTP overactivation has been implicated in mitochondrial dysfunction in aging and AD brains. This review summarizes the up-to-date progress in the study of mPTP in aging and AD and attempts to establish a link between brain aging and AD from a perspective of mPTP-mediated mitochondrial dysfunction.
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Date
2021-03-15
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MDPI
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Keywords
Mitochondrial permeability transition, Brain aging, Alzheimer’s disease
Citation
Jia, K.; Du, H. Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease. Cells 2021, 10, 649. https://doi.org/10.3390/cells10030649