Loading...
Inducing Partner Preference in Mice by Chemogenetic Stimulation of CA2 Hippocampal Subfield
Cymerblit-Sabba, Adi Smith, Adam S. Avram, Sarah K. Williams Stackmann, Michelle Korgan, Austin C. Tickerhoof, Maria C. Young, W. Scott
Cymerblit-Sabba, Adi
Smith, Adam S.
Avram, Sarah K. Williams
Stackmann, Michelle
Korgan, Austin C.
Tickerhoof, Maria C.
Young, W. Scott
Citations
Altmetric:
Abstract
Social recognition is fundamental for social decision making and the establishment of long-lasting affiliative behaviors in behaviorally complex social groups. It is a critical step in establishing a selective preference for a social partner or group member. C57BL/6J lab mice do not form monogamous relationships, and typically do not show prolonged social preferences for familiar mice. The CA2 hippocampal subfield plays a crucial role in social memory and optogenetic stimulation of inputs to the dorsal CA2 field during a short memory acquisition period can enhance and extend social memories in mice. Here, we show that partner preference in mice can be induced by chemogenetic selective stimulation of the monosynaptic projections from the hypothalamic paraventricular nucleus (PVN) to the CA2 during the cohabitation period. Specifically, male mice spend more time in social contact, grooming and huddling with the partner compared to a novel female. Preference was not induced by prolonging the cohabitation period and allowing more time for social interactions and males to sire pups with the familiar female. These results suggest that PVN-to-CA2 projections are part of an evolutionarily conserved neural circuitry underlying the formation of social preference and may promote behavioral changes with appropriate stimulation.
Description
Date
2020-04-23
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers Media
Collections
Files
Loading...
Cymerblit-Sabba_2020.pdf
Adobe PDF, 2 MB
Research Projects
Organizational Units
Journal Issue
Keywords
Partner preference, PVN, dCA2, Mice, Chemogenetic
Citation
Cymerblit-Sabba A, Smith AS, Williams Avram SK, Stackmann M, Korgan AC, Tickerhoof MC and Young WS (2020) Inducing Partner Preference in Mice by Chemogenetic Stimulation of CA2 Hippocampal Subfield. Front. Mol. Neurosci. 13:61. doi: 10.3389/fnmol.2020.00061