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Superior Therapeutic Potential of Young Bone Marrow Mesenchymal Stem Cells by Direct Intramyocardial Delivery in Aged Recipients with Acute Myocardial Infarction: In Vitro and In Vivo Investigation
Nayan, Madhur Paul, Arghya Chen, Guangyong Chiu, Ray C. J. Prakash, Satya Shum-Tim, Dominique
Nayan, Madhur
Paul, Arghya
Chen, Guangyong
Chiu, Ray C. J.
Prakash, Satya
Shum-Tim, Dominique
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Abstract
Bone-marrow-derived mesenchymal stem cells (MSCs) have been studied for treatment of myocardial infarction (MI). Since MSCs from older donors show quantitative and qualitative senescent changes, we hypothesized that a better outcome may be achieved if aged recipients are given MSCs obtained from young donors, rather than using their own autologous MSCs. Methods. In vitro studies compared properties of young and old MSCs. Aged rats randomized into 3 groups underwent coronary artery ligations and were then injected with either old (O) or young (Y) MSCs, or ligation alone. Echocardiography evaluated ejection fractions (EF). At 16 weeks, scar deposition was analyzed. Results. Old MSCs exhibited decreased cell viability, proliferation, and differentiation potentials. EF significantly improved early in both cell therapy groups (P < .05). However, at later stages of the study, group Y showed significantly better function which correlated with decreased scar deposition. Conclusions. The significant difference between young and old cells indicates the possible advantage for allotransplanting MSCs from young donors to elderly patients with MI.
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2011-05-27
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SAGE Publications
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Nayan, Madhur, Arghya Paul, Guangyong Chen, Day C. J. Chiu, Satya Prakash, and Dominique Shum-Tim. "Superior Therapeutic Potential of Young BoneMarrow Mesenchymal StemCells by Direct Intramyocardial Delivery in Aged Recipients with AcuteMyocardial Infarction: In Vitro and In Vivo Investigation." Journal of Tissue Engineering 2011 (2011)