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Hyperglycemia as a Risk Factor of Ischemic Stroke
Zhang, Ziyan Yan, Jingqi Shi, Honglian
Zhang, Ziyan
Yan, Jingqi
Shi, Honglian
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Abstract
Diabetes is considered a major risk factor for stroke and is associated with worsened stroke outcomes. Here, we discuss and summarize the mechanisms that have been associated with the increased risk of stroke due to the hyperglycemia in diabetes mellitus. In diabetic stroke models, hyperglycemia exaggerates the following damaging processes: acidosis, accumulation of reactive oxygen species/reactive nitrogen, inflammation and mitochondrial dysfunction. Understanding the mechanism of diabetes acting as a stroke risk factor will definitely assist to reveal issues related to drug metabolism and toxicity in diabetic stroke. In addition, it is suggested that future studies may focus on the mechanisms mediating blood-brain barrier and astrocytes dysfunction under hyperglycemic stroke.
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Date
2013-06-29
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OMICS
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Keywords
Diabetes, Stroke, Hyperglycemia, BBB, Neuroprotection
Citation
Ziyan Zhang, Jingqi Yan, Honglian Shi. "Hyperglycemia as a Risk Factor of Ischemic Stroke." J Drug Metab Toxicol. Author manuscript; available in PMC 2014 October 15. Published in final edited form as: J Drug Metab Toxicol. 2013 June 29; 4(4): 153. Published online 2013 June 29. http://dx.doi.org/10.4172/2157-7609.1000153