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Low-resolution structural modeling of protein interactome
Vakser, Ilya A.
Vakser, Ilya A.
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Abstract
Structural characterization of protein–protein interactions across the broad spectrum of scales is
key to our understanding of life at the molecular level. Low-resolution approach to protein
interactions is needed for modeling large interaction networks, given the significant level of
uncertainties in large biomolecular systems and the high-throughput nature of the task. Since only
a fraction of protein structures in interactome are determined experimentally, protein docking
approaches are increasingly focusing on modeled proteins. Current rapid advancement of
template-based modeling of protein–protein complexes is following a long standing trend in
structure prediction of individual proteins. Protein–protein templates are already available for
almost all interactions of structurally characterized proteins, and about one third of such templates
are likely correct.
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2013-04
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Elsevier
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Vakser, I. A. (2013). Low-resolution structural modeling of protein interactome. Current Opinion in Structural Biology, 23(2), 198–205. http://doi.org/10.1016/j.sbi.2012.12.003