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Cytotoxic Withanolide Constituents of Physalis longifolia
Zhang, Huaping Samadi, Abbas K. Gallagher, Robert J. Araya, Juan Jose Tong, Xiaoqin Day, Victor W. Cohen, Mark S. Kindscher, Kelly Gollapudi, Rao Timmermann, Barbara N.
Zhang, Huaping
Samadi, Abbas K.
Gallagher, Robert J.
Araya, Juan Jose
Tong, Xiaoqin
Day, Victor W.
Cohen, Mark S.
Kindscher, Kelly
Gollapudi, Rao
Timmermann, Barbara N.
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Abstract
Fourteen new withanolides, 1–14, named withalongolides A–N, respectively, were isolated from the aerial parts of Physalis longifolia together with eight known compounds (15–22). The structures of compounds 1–14 were elucidated through spectroscopic techniques and chemical methods. In addition, the structures of withanolides 1, 2, 3, and 6 were confirmed by X-ray crystallographic analysis. Using a MTS viability assay, eight withanolides (1, 2, 3, 7, 8, 15, 16, and 19) and four acetylated derivatives (1a, 1b, 2a, and 2b) showed potent cytotoxicity against human head and neck squamous cell carcinoma (JMAR and MDA-1986), melanoma (B16F10 and SKMEL-28), and normal fetal fibroblast (MRC-5) cells with IC50 values in the range between 0.067 and 9.3 μM.
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2011-11-08
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Journal of Natural Products
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Zhang, Huaping, Abbas K. Samadi, Robert J. Gallagher, Juan J. Araya, Xiaoqin Tong, Victor W. Day, Mark S. Cohen, Kelly Kindscher, Rao Gollapudi, and Barbara N. Timmermann. "Cytotoxic Withanolide Constituents OfPhysalis Longifolia." Journal of Natural Products 74.12 (2011): 2532-544.