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Metal-free transannulation reaction of indoles with nitrostyrenes: a simple practical synthesis of 3-substituted 2-quinolones
Aksenov, Alexander V. Smirnov, Alexander N. Aksenov, Nicolai A. Aksenova, Inna V. Frolova, Liliya V. Kornienko, Alexander Magedov, Igor V. Rubin, Michael
Aksenov, Alexander V.
Smirnov, Alexander N.
Aksenov, Nicolai A.
Aksenova, Inna V.
Frolova, Liliya V.
Kornienko, Alexander
Magedov, Igor V.
Rubin, Michael
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Abstract
3-Substituted 2-quinolones are obtained via a novel, metal-free transannulation reaction of 2-substituted indoles with 2-nitroalkenes in polyphosphoric acid. The reaction can be used in conjunction with the Fisher indole synthesis offering a practical three-component heteroannulation methodology to produce 2-quinolones from arylhydrazines, 2-nitroalkenes and acetophenone.
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2016-07-15
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Royal Society of Chemistry
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Aksenov, Alexander V., Alexander N. Smirnov, Nicolai A. Aksenov, Inna V. Aksenova, Liliya V. Frolova, Alexander Kornienko, Igor V. Magedov, and Michael Rubin. "Metal-free Transannulation Reaction of Indoles with Nitrostyrenes: A Simple Practical Synthesis of 3-substituted 2-quinolones." Chemical Communications 49.81 (2013): 9305.