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Construct validity of a continuous metabolic syndrome score in children
Eisenmann, Joey C. Laurson, Kelly R. DuBose, Katrina D. Smith, Bryan K. Donnelly, Joseph E.
Eisenmann, Joey C.
Laurson, Kelly R.
DuBose, Katrina D.
Smith, Bryan K.
Donnelly, Joseph E.
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Abstract
Objective: The primary purpose of this study was to examine the construct validity of a continuous metabolic syndrome score (cMetS) in children. The secondary purpose was to identify a cutpoint value(s) for an adverse
cMetS based on receiver operating characteristic (ROC) curve analysis.
Methods: 378 children aged 7 to 9 years were assessed for the metabolic syndrome which was determined by
age-modified cutpoints. High-density-lipoprotein cholesterol, triglycerides, the homeostasis assessment model of insulin resistance, mean arterial pressure, and waist circumference were used to create a cMetS for each subject.
Results: About half of the subjects did not possess any risk factors while about 5% possessed the metabolic
syndrome. There was a graded relationship between the cMetS and the number of adverse risk factors. The cMetS
was lowest in the group with no adverse risk factors (-1.59 ± 1.76) and highest in those possessing the metabolic syndrome (≥3 risk factors) (7.05 ± 2.73). The cutoff level yielding the maximal sensitivity and specificity for predicting the presence of the metabolic syndrome was a cMetS of 3.72 (sensitivity = 100%, specificity = 93.9%,
and the area of the curve = 0.978 (0.957-0.990, 95% confidence intervals).
Conclusion: The results demonstrate the construct validity for the cMetS in children. Since there are several drawbacks to identifying a single cut-point value for the cMetS based on this sample, we urge researchers to use the approach herein to validate and create a cMetS that is specific to their study population.
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2010-01-28
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BioMed Central
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Eisenmann, Joey C, Kelly R Laurson, Katrina D DuBose, Bryan K Smith, and Joseph E Donnelly. 2010. “Construct Validity of a Continuous Metabolic Syndrome Score in Children.” Diabetology & Metabolic Syndrome 2:8. http://dx.doi.org/10.1186/1758-5996-2-8.