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Deciphering the role of substrate stiffness to enhance internalization efficiency of plasmid DNA in stem cells using lipid-based nanocarriers

Modaresi, Saman
; 
Pacelli, Settimio
; 
Whitlow, Jonathan
; 
Paul, Arghya
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Abstract
This study investigates the role of substrate stiffness on non-viral transfection of human adipose-derived stem cells (hASCs) with the aim to maximize hASCs expression of vascular endothelial growth factor (VEGF). The results confirm the direct effect of substrate stiffness in regulating cytoskeletal remodeling and corresponding plasmid internalization.
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Date
2018-04-06
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Royal Society of Chemistry
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Chemical & Petroleum Engineering Scholarly Works
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Modaresi, S., Pacelli, S., Whitlow, J., & Paul, A. (2018). Deciphering the role of substrate stiffness to enhance internalization efficiency of plasmid DNA in stem cells using lipid-based nanocarriers. Nanoscale, 10(19), 8947–8952. http://doi.org/10.1039/c8nr01516c
URI
https://hdl.handle.net/1808/26458
DOI
10.1039/C8NR01516C
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