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Mitotic and antiapoptotic effects of nanoparticles coencapsulating human VEGF and human angiopoietin-1 on vascular endothelial cells
Khan, Afshan Afsar Paul, Arghya Abbasi, Sana Prakash, Satya
Khan, Afshan Afsar
Paul, Arghya
Abbasi, Sana
Prakash, Satya
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Abstract
Research towards the application of nanoparticles as carrier vehicles for the delivery of therapeutic agents is increasingly gaining importance. The angiogenic growth factors, human vascular endothelial growth factor (VEGF) and human angiopoietin-1 are known to prevent vascular endothelial cell apoptosis and in fact to stimulate human vascular endothelial cell (HUVEC) proliferation. This paper aims to study the combined effect of these bioactive proteins coencapsulated in human serum albumin nanoparticles on HUVECs and to evaluate the potential application of this delivery system towards therapeutic angiogenesis.
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Date
2011-05-24
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Dove Medical Press
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Keywords
Growth factors, Encapsulation, Nanoparticles, Nanobiotechnology, Angiogenesis, Regenerative medicine
Citation
Prakash, Satya, Afshan Afsar Khan, Arghya Paul, and Sana Abbasi. "Mitotic and Antiapoptotic Effects of Nanoparticles Coencapsulating Human VEGF and Human Angiopoietin-1 on Vascular Endothelial Cells." International Journal of Nanomedicine IJN (2011): 1069. http://dx.doi.org/10.2147/IJN.S15054.