Loading...
Fabrication of a Double-Cross-Linked Interpenetrating Polymeric Network (IPN) Hydrogel Surface Modified with Polydopamine to Modulate the Osteogenic Differentiation of Adipose-Derived Stem Cells
Pacelli, Settimio Rampetsreiter, Kyle Modaresi, Saman Subham, Siddharth Chakravarti, Aparna R. Lohfeld, Stefan Detamore, Michael S. Paul, Arghya
Pacelli, Settimio
Rampetsreiter, Kyle
Modaresi, Saman
Subham, Siddharth
Chakravarti, Aparna R.
Lohfeld, Stefan
Detamore, Michael S.
Paul, Arghya
Citations
Altmetric:
Abstract
Hydrogel surface properties can be modified to form bioactive interfaces to modulate the osteogenic differentiation of stem cells. In this work, a hydrogel made of gelatin methacrylamide (GelMA) and alginate was designed and tested as a scaffold to control stem-cell osteogenic differentiation. The hydrogel’s surface was treated with polydopamine (pDA) to create an adhesive layer for the adsorption of the osteoinductive drug dexamethasone (Dex). The presence of the pDA coating enhanced Dex adsorption and retention over 21 days. This effect resulted in a delay in the osteogenic differentiation of hASCs cultured on the hydrogel treated with a pDA layer.
Description
This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials and Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/acsami.8b05200.
Date
2018-07-03
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
Research Projects
Organizational Units
Journal Issue
Keywords
Hydrogel coating, Osteogenic differentiation, Polydopamine, Regenerative medicine, Surface modification
Citation
Pacelli, S., Rampetsreiter, K., Modaresi, S., Subham, S., Chakravarti, A. R., Lohfeld, S., … Paul, A. (2018). Fabrication of a Double-Cross-Linked Interpenetrating Polymeric Network (IPN) Hydrogel Surface Modified with Polydopamine to Modulate the Osteogenic Differentiation of Adipose-Derived Stem Cells. ACS applied materials & interfaces, 10(30), 24955–24962. doi:10.1021/acsami.8b05200