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Resistance to natural and synthetic gene drive systems
Price, Tom A. R. Windbichler, Nikolai Unckless, Robert L. Sutter, Andreas Runge, Jan-Niklas Ross, Perran A. Pomiankowski, Andrew Nuckolls, Nicole L. Montchamp-Moreau, Catherine Mideo, Nicole
Price, Tom A. R.
Windbichler, Nikolai
Unckless, Robert L.
Sutter, Andreas
Runge, Jan-Niklas
Ross, Perran A.
Pomiankowski, Andrew
Nuckolls, Nicole L.
Montchamp-Moreau, Catherine
Mideo, Nicole
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Abstract
Scientists are rapidly developing synthetic gene drive elements intended for release into natural populations. These are intended to control or eradicate disease vectors and pests, or to spread useful traits through wild populations for disease control or conservation purposes. However, a crucial problem for gene drives is the evolution of resistance against them, preventing their spread. Understanding the mechanisms by which populations might evolve resistance is essential for engineering effective gene drive systems. This review summarizes our current knowledge of drive resistance in both natural and synthetic gene drives. We explore how insights from naturally occurring and synthetic drive systems can be integrated to improve the design of gene drives, better predict the outcome of releases and understand genomic conflict in general.
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Date
2020-09-24
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Publisher
Wiley
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Keywords
CRISPR-Cas9, Fitness costs, Meiotic drive, Population suppression, Selfish genetic elements, Sex ratio distorter, Transposable elements, Wolbachia
Citation
Price, T., Windbichler, N., Unckless, R. L., Sutter, A., Runge, J. N., Ross, P. A., Pomiankowski, A., Nuckolls, N. L., Montchamp-Moreau, C., Mideo, N., Martin, O. Y., Manser, A., Legros, M., Larracuente, A. M., Holman, L., Godwin, J., Gemmell, N., Courret, C., Buchman, A., Barrett, L. G., … Lindholm, A. K. (2020). Resistance to natural and synthetic gene drive systems. Journal of evolutionary biology, 33(10), 1345–1360. https://doi.org/10.1111/jeb.13693