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Photoacoustic contrast imaging of biological tissues with nanodiamonds fabricated for high near-infrared absorbance
Zhang, Ti Cui, Huizhong Fang, Chia-Yi Su, Long-Jyun Ren, Shenqiang Chang, Huan-Cheng Yang, Xinmai Forrest, M. Laird
Zhang, Ti
Cui, Huizhong
Fang, Chia-Yi
Su, Long-Jyun
Ren, Shenqiang
Chang, Huan-Cheng
Yang, Xinmai
Forrest, M. Laird
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Abstract
Radiation-damaged nanodiamonds (DNDs) are potentially ideal optical contrast agents for photoacoustic (PA) imaging in biological tissues due to their low toxicity and high optical absorbance. PA imaging contrast agents have been limited to quantum dots and gold particles, since most existing carbon-based nanoparticles, including fluorescent nanodiamonds, do not have sufficient optical absorption in the near-infrared (NIR) range. A new DND by He+ ion beam irradiation with very high NIR absorption was synthesized. These DNDs produced a 71-fold higher PA signal on a molar basis than similarly dimensioned gold nanorods, and 7.1 fmol of DNDs injected into rodents could be clearly imaged 3 mm below the skin surface with PA signal enhancement of 567% using an 820-nm laser wavelength.
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Date
2013-02-12
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Publisher
Society of Photo-optical Instrumentation Engineers
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Keywords
Photoacoustic imaging, nanodiamonds, Au nanorods, Optical contrast agent
Citation
Zhang, Ti, Huizhong Cui, Chia-Yi Fang, Long-Jyun Su, Shenqiang Ren, Huan-Cheng Chang, Xinmai Yang, and M. Laird Forrest. "Photoacoustic Contrast Imaging of Biological Tissues with Nanodiamonds Fabricated for High Near-infrared Absorbance." J. Biomed. Opt Journal of Biomedical Optics 18.2 (2013): 026018. http://dx.doi.org/10.1117/1.JBO.18.2.026018