Loading...
High-precision, non-invasive anti-microvascular approach via concurrent ultrasound and laser irradiation
Hu, Zizhong Zhang, Haonan Mordovanakis, Aghapi Paulus, Yannis M. Liu, Qinghuai Wang, Xueding Yang, Xinmai
Hu, Zizhong
Zhang, Haonan
Mordovanakis, Aghapi
Paulus, Yannis M.
Liu, Qinghuai
Wang, Xueding
Yang, Xinmai
Citations
Altmetric:
Abstract
Antivascular therapy represents a proven strategy to treat angiogenesis. By applying synchronized ultrasound bursts and nanosecond laser irradiation, we developed a novel, selective, non-invasive, localized antivascular method, termed photo-mediated ultrasound therapy (PUT). PUT takes advantage of the high native optical contrast among biological tissues and can treat microvessels without causing collateral damage to the surrounding tissue. In a chicken yolk sac membrane model, under the same ultrasound parameters (1 MHz at 0.45 MPa and 10 Hz with 10% duty cycle), PUT with 4 mJ/cm2 and 6 mJ/cm2 laser fluence induced 51% (p = 0.001) and 37% (p = 0.018) vessel diameter reductions respectively. With 8 mJ/cm2 laser fluence, PUT would yield vessel disruption (90%, p < 0.01). Selectivity of PUT was demonstrated by utilizing laser wavelengths at 578 nm or 650 nm, where PUT selectively shrank veins or occluded arteries. In a rabbit ear model, PUT induced a 68.5% reduction in blood perfusion after 7 days (p < 0.001) without damaging the surrounding cells. In vitro experiments in human blood suggested that cavitation may play a role in PUT. In conclusion, PUT holds significant promise as a novel non-invasive antivascular method with the capability to precisely target blood vessels.
Description
Date
2017-01-11
Journal Title
Journal ISSN
Volume Title
Publisher
Nature Research
Collections
Files
Loading...
Yang_2017.pdf
Adobe PDF, 1.75 MB
Research Projects
Organizational Units
Journal Issue
Keywords
Biomedical engineering, Radiotherapy, Surgical oncology, Translational research
Citation
Hu, Z. et al. High-precision, non-invasive anti-microvascular approach via concurrent ultrasound and laser irradiation. Sci. Rep. 7, 40243; doi: 10.1038/srep40243 (2017).